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It is clear that ARs interactions with its protein network, as well as the type of ARE that it binds, can markedly influence the transcriptional output from DNA-bound AR, and, thus, a one-size-fits-all mechanism by which AR regulates transcription from ARE-containing genes does not apply

doi: 10.1172/JCI105637

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Moreover, we found that silencing Cpt1a using siRNA triggered the activation of the GSDMD-NT fragment

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Acute Presentation Lethargy, altered mental status Nausea, vomiting Hepatomegaly Laboratory Findings Hypoglycemia Metabolic acidosis with anion gap Hyperammonemia There are two types of presentation, depending on the severity of the metabolic defect